Assay Detail
Functional
CHEMBL4313748
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.95 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.12 |
| CHEMBL337173 | — | — | 1 | 5.56 |
| CHEMBL4521092 | — | — | 1 | 5.41 |
| CHEMBL4466461 | — | — | 1 | 5.35 |
| CHEMBL4566962 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.52 | nM | 8.12 |
| CHEMBL337173 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL4521092 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL4466461 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4566962 | — | IC50 | = | 4920.0 | nM | 5.31 |