Assay Detail
Functional
CHEMBL4313828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against luciferase expressing intracellular amastigote stage of Leishmania infantum infected in human THP1 cells assessed as parasite growth inhibition measured after 48 to 72 hrs by steady-glo luciferase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.57 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464312 | — | — | 1 | 5.73 |
| CHEMBL4441917 | — | — | 1 | 5.68 |
| CHEMBL4567447 | — | — | 1 | 5.62 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.60 |
| CHEMBL4575467 | — | — | 1 | 5.57 |
| CHEMBL4447054 | — | — | 1 | 5.57 |
| CHEMBL4469979 | — | — | 1 | 5.22 |
| CHEMBL4567834 | — | — | 1 | - |
| CHEMBL4538581 | — | — | 1 | - |
| CHEMBL4457377 | — | — | 1 | - |
| CHEMBL4592720 | — | — | 1 | - |
| CHEMBL4520438 | — | — | 1 | - |
| CHEMBL4448476 | — | — | 1 | - |
| CHEMBL4517741 | — | — | 1 | - |
| CHEMBL4541910 | — | — | 1 | - |
| CHEMBL4592506 | — | — | 1 | - |
| CHEMBL4458341 | — | — | 1 | - |
| CHEMBL4563463 | — | — | 1 | - |
| CHEMBL4439246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464312 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4441917 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4567447 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4575467 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4447054 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4469979 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4567834 | — | EC50 | - | — | - | |
| CHEMBL4538581 | — | EC50 | - | — | - | |
| CHEMBL4457377 | — | EC50 | - | — | - | |
| CHEMBL4592720 | — | EC50 | - | — | - | |
| CHEMBL4520438 | — | EC50 | - | — | - | |
| CHEMBL4448476 | — | EC50 | - | — | - | |
| CHEMBL4517741 | — | EC50 | - | — | - | |
| CHEMBL4541910 | — | EC50 | - | — | - | |
| CHEMBL4592506 | — | EC50 | - | — | - | |
| CHEMBL4458341 | — | EC50 | - | — | - | |
| CHEMBL4563463 | — | EC50 | - | — | - | |
| CHEMBL4439246 | — | EC50 | - | — | - |