Assay Detail
Functional
CHEMBL4314178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.92 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | — | 1 | 5.57 |
| CHEMBL295316 | PLUMBAGIN | 1.0 | 1 | 5.39 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | — | 1 | 5.21 |
| CHEMBL402468 | — | — | 1 | 5.20 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.17 |
| CHEMBL4452484 | — | — | 1 | 5.13 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.05 |
| CHEMBL429095 | — | — | 1 | 5.03 |
| CHEMBL4450909 | — | — | 1 | 4.91 |
| CHEMBL1578997 | — | — | 1 | 4.84 |
| CHEMBL4450216 | — | — | 1 | 4.83 |
| CHEMBL4559690 | — | — | 1 | 4.78 |
| CHEMBL189010 | — | — | 1 | 4.78 |
| CHEMBL100206 | — | — | 1 | 4.74 |
| CHEMBL492025 | — | — | 1 | 4.67 |
| CHEMBL4551631 | — | — | 1 | 4.67 |
| CHEMBL365781 | — | — | 1 | 4.55 |
| CHEMBL1464721 | — | — | 1 | 4.54 |
| CHEMBL92659 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9470 | SHIKONIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL295316 | PLUMBAGIN | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL402468 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL535 | SUNITINIB | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4452484 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL590 | MENADIONE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL429095 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4450909 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL1578997 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4450216 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4559690 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL189010 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL100206 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL492025 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4551631 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL365781 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL1464721 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL92659 | — | IC50 | = | 30900.0 | nM | 4.51 |