Assay Detail
Binding
CHEMBL4314264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.26 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.23 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.26 |
| CHEMBL4454906 | — | — | 1 | 4.98 |
| CHEMBL4538061 | — | — | 1 | 4.58 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4454906 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4538061 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |