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Assay Detail

CHEMBL4314265

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Bai P, Wang K, Zhang P, Shi J, Cheng X, Zhang Q, Zheng C, Cheng Y, Yang J, Lu X, Sang Z.
Eur J Med Chem (2019) 183 : 111737 -111737
PubMed 31581002 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.53 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL887 RASAGILINE 4.0 1 7.55
CHEMBL4537240 1 6.24
CHEMBL4454906 1 6.18
CHEMBL4437622 1 6.14
CHEMBL4456071 1 6.06
CHEMBL4552080 1 5.96
CHEMBL92401 IPRONIAZID 2.0 1 5.87
CHEMBL4540199 1 5.82
CHEMBL4543178 1 5.80
CHEMBL4461873 1 5.68
CHEMBL4474824 1 5.47
CHEMBL4556096 1 5.09
CHEMBL4466366 1 5.08
CHEMBL4451613 1 5.01
CHEMBL4476091 1 4.90
CHEMBL4473461 1 4.81
CHEMBL4538061 1 4.78
CHEMBL4575664 1 4.76
CHEMBL4443141 1 4.73
CHEMBL4476735 1 4.67
CHEMBL502 DONEPEZIL 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL887 RASAGILINE IC50 = 28.1 nM 7.55
CHEMBL4537240 IC50 = 570.0 nM 6.24
CHEMBL4454906 IC50 = 660.0 nM 6.18
CHEMBL4437622 IC50 = 730.0 nM 6.14
CHEMBL4456071 IC50 = 870.0 nM 6.06
CHEMBL4552080 IC50 = 1100.0 nM 5.96
CHEMBL92401 IPRONIAZID IC50 = 1350.0 nM 5.87
CHEMBL4540199 IC50 = 1500.0 nM 5.82
CHEMBL4543178 IC50 = 1600.0 nM 5.80
CHEMBL4461873 IC50 = 2100.0 nM 5.68
CHEMBL4474824 IC50 = 3400.0 nM 5.47
CHEMBL4556096 IC50 = 8100.0 nM 5.09
CHEMBL4466366 IC50 = 8300.0 nM 5.08
CHEMBL4451613 IC50 = 9700.0 nM 5.01
CHEMBL4476091 IC50 = 12700.0 nM 4.90
CHEMBL4473461 IC50 = 15400.0 nM 4.81
CHEMBL4538061 IC50 = 16800.0 nM 4.78
CHEMBL4575664 IC50 = 17200.0 nM 4.76
CHEMBL4443141 IC50 = 18500.0 nM 4.73
CHEMBL4476735 IC50 = 21600.0 nM 4.67
CHEMBL502 DONEPEZIL IC50 - -