Assay Detail
Binding
CHEMBL4314366
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Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.97 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571862 | — | — | 1 | 7.54 |
| CHEMBL2377590 | — | — | 1 | 7.20 |
| CHEMBL4454176 | — | — | 1 | 7.15 |
| CHEMBL4483554 | — | — | 1 | 7.09 |
| CHEMBL4571321 | — | — | 1 | 7.07 |
| CHEMBL2377591 | — | — | 1 | 6.80 |
| CHEMBL4515160 | — | — | 1 | 6.52 |
| CHEMBL4591440 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571862 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2377590 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL4454176 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL4483554 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL4571321 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2377591 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL4515160 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL4591440 | — | Ki | = | 427.0 | nM | 6.37 |