Assay Detail
Binding
CHEMBL4314367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.07 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1237021 | LURASIDONE | 4.0 | 1 | 9.30 |
| CHEMBL2105760 | BREXPIPRAZOLE | 4.0 | 1 | 8.43 |
| CHEMBL4483554 | — | — | 1 | 7.60 |
| CHEMBL4571862 | — | — | 1 | 7.30 |
| CHEMBL2028019 | CARIPRAZINE | 4.0 | 1 | 6.96 |
| CHEMBL2377590 | — | — | 1 | 6.71 |
| CHEMBL4591440 | — | — | 1 | 6.50 |
| CHEMBL2377591 | — | — | 1 | 6.46 |
| CHEMBL4454176 | — | — | 1 | 6.34 |
| CHEMBL4571321 | — | — | 1 | 6.19 |
| CHEMBL4515160 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1237021 | LURASIDONE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2105760 | BREXPIPRAZOLE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4483554 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4571862 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL2028019 | CARIPRAZINE | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL2377590 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL4591440 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL2377591 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL4454176 | — | Ki | = | 458.0 | nM | 6.34 |
| CHEMBL4571321 | — | Ki | = | 641.0 | nM | 6.19 |
| CHEMBL4515160 | — | Ki | = | 1158.0 | nM | 5.94 |