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Assay Detail

CHEMBL4314373

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5-HT2CR (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL225)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Wróbel MZ, Chodkowski A, Herold F, Marciniak M, Dawidowski M, Siwek A, Starowicz G, Stachowicz K, Szewczyk B, Nowak G, Belka M, Bączek T, Satała G, Bojarski AJ, Turło J.
Eur J Med Chem (2019) 183 : 111736 -111736
PubMed 31586817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.10 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1200938 METHYSERGIDE MALEATE 4.0 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1200938 METHYSERGIDE MALEATE Ki = 0.7943 nM 9.10