Assay Detail
Functional
CHEMBL4314736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL4557538 | — | — | 1 | 7.10 |
| CHEMBL4443028 | — | — | 1 | 6.82 |
| CHEMBL4589145 | — | — | 1 | 6.70 |
| CHEMBL4561800 | — | — | 1 | 6.39 |
| CHEMBL4582357 | — | — | 1 | 6.28 |
| CHEMBL4444234 | — | — | 1 | 6.09 |
| CHEMBL4539206 | — | — | 1 | 6.05 |
| CHEMBL4464464 | — | — | 1 | 6.03 |
| CHEMBL4528176 | — | — | 1 | 6.01 |
| CHEMBL4562454 | — | — | 1 | 5.96 |
| CHEMBL4468218 | — | — | 1 | 5.89 |
| CHEMBL4571897 | — | — | 1 | 5.85 |
| CHEMBL4563751 | — | — | 1 | 5.81 |
| CHEMBL4440483 | — | — | 1 | 5.79 |
| CHEMBL4467910 | — | — | 1 | 5.77 |
| CHEMBL4577363 | — | — | 1 | 5.74 |
| CHEMBL4469165 | — | — | 1 | 5.71 |
| CHEMBL4539896 | — | — | 1 | 5.70 |
| CHEMBL4469735 | — | — | 1 | 5.65 |
| CHEMBL4524454 | — | — | 1 | 5.61 |
| CHEMBL4434662 | — | — | 1 | 5.59 |
| CHEMBL4457446 | — | — | 1 | 5.54 |
| CHEMBL141689 | MYOSEVERIN | — | 1 | 5.51 |
| CHEMBL4574731 | — | — | 1 | 5.32 |
| CHEMBL4438549 | — | — | 1 | 5.29 |
| CHEMBL4572316 | — | — | 1 | 5.28 |
| CHEMBL4440747 | — | — | 1 | 5.24 |
| CHEMBL4471998 | — | — | 1 | 5.24 |
| CHEMBL4567193 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4557538 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4443028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4589145 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4561800 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4582357 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4444234 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4539206 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4464464 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4528176 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4562454 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4468218 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4571897 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4563751 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4440483 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4467910 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4577363 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL4469165 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4539896 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4469735 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4524454 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4434662 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4457446 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL141689 | MYOSEVERIN | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4574731 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL4438549 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL4572316 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL4440747 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4471998 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4567193 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL4453700 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL4471964 | — | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL4451857 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL4438621 | — | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL4455742 | — | IC50 | = | 9830.0 | nM | 5.01 |
| CHEMBL4560549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4553382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4475189 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4575346 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4440557 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4577899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4439479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4436566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4459286 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4535146 | — | IC50 | > | 10000.0 | nM | - |