Assay Detail
Binding
CHEMBL4315186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC1 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.26 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.21 |
| CHEMBL4438378 | — | — | 1 | 6.63 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.51 |
| CHEMBL4554522 | — | — | 1 | 6.05 |
| CHEMBL4444554 | — | — | 1 | 5.99 |
| CHEMBL4551593 | — | — | 1 | 5.67 |
| CHEMBL4572459 | — | — | 1 | 5.51 |
| CHEMBL4461884 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 6.22 | nM | 8.21 |
| CHEMBL4438378 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4554522 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL4444554 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4551593 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4572459 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4461884 | — | IC50 | = | 3370.0 | nM | 5.47 |