Assay Detail
Functional
CHEMBL4315188
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Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.38 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.19 |
| CHEMBL4438378 | — | — | 1 | 5.54 |
| CHEMBL569864 | — | — | 1 | 5.48 |
| CHEMBL4551593 | — | — | 1 | 5.31 |
| CHEMBL4461884 | — | — | 1 | 5.31 |
| CHEMBL4554522 | — | — | 1 | 5.14 |
| CHEMBL4572459 | — | — | 1 | 5.11 |
| CHEMBL4444554 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4438378 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL569864 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4551593 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4461884 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4554522 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4572459 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4444554 | — | EC50 | = | 12000.0 | nM | 4.92 |