Assay Detail
Functional
CHEMBL4315232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against ring stage Plasmodium falciparum 3D7 incubated for 48 hrs by Hoechst 33342 staining based fluorescence based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.91 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.47 |
| CHEMBL4461884 | — | — | 1 | 7.02 |
| CHEMBL4551593 | — | — | 1 | 6.96 |
| CHEMBL4554522 | — | — | 1 | 6.84 |
| CHEMBL569864 | — | — | 1 | 6.82 |
| CHEMBL4444554 | — | — | 1 | 6.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4461884 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4551593 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4554522 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL569864 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4444554 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 274.0 | nM | 6.56 |