Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4315320

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 12 (CHEMBL3242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.
Abo-Ashour MF, Eldehna WM, Nocentini A, Bonardi A, Bua S, Ibrahim HS, Elaasser MM, Kryštof V, Jorda R, Gratteri P, Abou-Seri SM, Supuran CT.
Eur J Med Chem (2019) 184 : 111768 -111768
PubMed 31629164 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.01 8.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4099138 1 8.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4099138 Ki = 9.7 nM 8.01