Assay Detail
Binding
CHEMBL4315807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DPP4 in human serum assessed as decrease in p-nitroaniline formation using Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by incubation with substrate for 15 mins by microplate reader analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitrothiadiazolo[3,2-a]pyrimidines as promising antiglycating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.09 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.82 |
| CHEMBL4571225 | — | — | 1 | 4.25 |
| CHEMBL4554062 | — | — | 1 | 4.16 |
| CHEMBL4535561 | — | — | 1 | 4.12 |
| CHEMBL4540237 | — | — | 1 | - |
| CHEMBL4582763 | — | — | 1 | - |
| CHEMBL4557028 | — | — | 1 | - |
| CHEMBL4471409 | — | — | 1 | - |
| CHEMBL4448038 | — | — | 1 | - |
| CHEMBL4525051 | — | — | 1 | - |
| CHEMBL4435578 | — | — | 1 | - |
| CHEMBL4567960 | — | — | 1 | - |
| CHEMBL4463269 | — | — | 1 | - |
| CHEMBL4466627 | — | — | 1 | - |
| CHEMBL4563602 | — | — | 1 | - |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | - |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | - |
| CHEMBL4555157 | — | — | 1 | - |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4571225 | — | IC50 | = | 55870.0 | nM | 4.25 |
| CHEMBL4554062 | — | IC50 | = | 68510.0 | nM | 4.16 |
| CHEMBL4535561 | — | IC50 | = | 76170.0 | nM | 4.12 |
| CHEMBL4540237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4582763 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4557028 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4471409 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4448038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4525051 | — | IC50 | = | 121300.0 | nM | - |
| CHEMBL4435578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4567960 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4463269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4466627 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4563602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL225304 | PIMAGEDINE | IC50 | - | — | - | |
| CHEMBL595 | PIOGLITAZONE | IC50 | - | — | - | |
| CHEMBL4555157 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL134342 | THIOCTIC ACID | IC50 | - | — | - |