Assay Detail
Binding
CHEMBL4315904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GGDPS (unknown origin) using [14C] IPP and FPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min by liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel benzimidazole phosphonates as potential inhibitors of protein prenylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.38 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457423 | — | — | 1 | 4.69 |
| CHEMBL4529809 | — | — | 1 | 4.39 |
| CHEMBL4459281 | — | — | 1 | 4.06 |
| CHEMBL4589567 | — | — | 1 | - |
| CHEMBL4460301 | — | — | 1 | - |
| CHEMBL4564870 | — | — | 1 | - |
| CHEMBL4514446 | — | — | 1 | - |
| CHEMBL4438314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457423 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL4529809 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4459281 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4589567 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4460301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4564870 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4514446 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4438314 | — | IC50 | > | 100000.0 | nM | - |