Assay Detail
Binding
CHEMBL4316151
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Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped flow CO2 hydrase assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.65 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587956 | — | — | 1 | 8.36 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4559106 | — | — | 1 | 8.11 |
| CHEMBL4585562 | — | — | 1 | 8.09 |
| CHEMBL4555991 | — | — | 1 | 8.09 |
| CHEMBL4529889 | — | — | 1 | 8.01 |
| CHEMBL4578451 | — | — | 1 | 8.00 |
| CHEMBL4458130 | — | — | 1 | 7.99 |
| CHEMBL4446087 | — | — | 1 | 7.79 |
| CHEMBL4470233 | — | — | 1 | 7.75 |
| CHEMBL4461308 | — | — | 1 | 7.75 |
| CHEMBL4455591 | — | — | 1 | 7.70 |
| CHEMBL4452122 | — | — | 1 | 7.66 |
| CHEMBL4441461 | — | — | 1 | 7.62 |
| CHEMBL4520887 | — | — | 1 | 7.62 |
| CHEMBL4552517 | — | — | 1 | 7.62 |
| CHEMBL4561594 | — | — | 1 | 7.58 |
| CHEMBL4579505 | — | — | 1 | 7.58 |
| CHEMBL4538248 | — | — | 1 | 7.53 |
| CHEMBL4535291 | — | — | 1 | 7.53 |
| CHEMBL4441389 | — | — | 1 | 7.51 |
| CHEMBL4462487 | — | — | 1 | 7.46 |
| CHEMBL4586998 | — | — | 1 | 7.42 |
| CHEMBL4553410 | — | — | 1 | 7.34 |
| CHEMBL4538508 | — | — | 1 | 7.32 |
| CHEMBL4459278 | — | — | 1 | 7.30 |
| CHEMBL4526879 | — | — | 1 | 7.23 |
| CHEMBL4555212 | — | — | 1 | 7.19 |
| CHEMBL4458902 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587956 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4559106 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4585562 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL4555991 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4529889 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL4578451 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL4458130 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL4446087 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL4470233 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL4461308 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL4455591 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL4452122 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL4520887 | — | Ki | = | 23.8 | nM | 7.62 |
| CHEMBL4552517 | — | Ki | = | 23.8 | nM | 7.62 |
| CHEMBL4441461 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL4561594 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4579505 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL4538248 | — | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL4535291 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL4441389 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4462487 | — | Ki | = | 34.4 | nM | 7.46 |
| CHEMBL4586998 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL4553410 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL4538508 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL4459278 | — | Ki | = | 49.7 | nM | 7.30 |
| CHEMBL4526879 | — | Ki | = | 59.3 | nM | 7.23 |
| CHEMBL4555212 | — | Ki | = | 64.3 | nM | 7.19 |
| CHEMBL4458902 | — | Ki | = | 73.6 | nM | 7.13 |
| CHEMBL4458904 | — | Ki | = | 103.9 | nM | 6.98 |
| CHEMBL4455961 | — | Ki | = | 105.0 | nM | 6.98 |