Assay Detail
Functional
CHEMBL4316283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant assessed as reduction in cell viability incubated for 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBM5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.38 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536640 | — | — | 1 | 7.92 |
| CHEMBL4559506 | — | — | 1 | 7.80 |
| CHEMBL4543075 | — | — | 1 | 7.68 |
| CHEMBL4444616 | — | — | 1 | 7.66 |
| CHEMBL4586068 | — | — | 1 | 7.58 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536640 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4559506 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4543075 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4444616 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4586068 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 2421.0 | nM | 5.62 |