Assay Detail
Functional
CHEMBL4316290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.35 | 7.47 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536640 | — | — | 2 | 7.47 |
| CHEMBL4586068 | — | — | 2 | 7.46 |
| CHEMBL4543075 | — | — | 2 | 7.29 |
| CHEMBL4559506 | — | — | 2 | 7.29 |
| CHEMBL4444616 | — | — | 2 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536640 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4586068 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4543075 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4559506 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4444616 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4444616 | — | Inhibition | - | % | - | |
| CHEMBL4543075 | — | Inhibition | - | % | - | |
| CHEMBL4559506 | — | Inhibition | - | % | - | |
| CHEMBL4586068 | — | Inhibition | - | % | - | |
| CHEMBL4536640 | — | Inhibition | - | % | - |