Assay Detail
Binding
CHEMBL4316481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 81 | 7.73 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4513684 | — | — | 1 | 9.40 |
| CHEMBL4451500 | — | — | 1 | 9.30 |
| CHEMBL4446052 | — | — | 1 | 9.28 |
| CHEMBL4437818 | — | — | 1 | 9.10 |
| CHEMBL4475496 | — | — | 1 | 9.08 |
| CHEMBL4442511 | — | — | 1 | 9.00 |
| CHEMBL4574321 | — | — | 1 | 9.00 |
| CHEMBL4475073 | — | — | 1 | 9.00 |
| CHEMBL4588838 | — | — | 1 | 8.89 |
| CHEMBL4584546 | — | — | 1 | 8.85 |
| CHEMBL4466140 | — | — | 1 | 8.85 |
| CHEMBL4539233 | — | — | 1 | 8.77 |
| CHEMBL4450456 | — | — | 1 | 8.77 |
| CHEMBL4562296 | — | — | 1 | 8.77 |
| CHEMBL4569008 | — | — | 1 | 8.72 |
| CHEMBL4450545 | — | — | 1 | 8.70 |
| CHEMBL4593681 | — | — | 1 | 8.70 |
| CHEMBL4444201 | — | — | 1 | 8.62 |
| CHEMBL4450306 | — | — | 1 | 8.60 |
| CHEMBL4470832 | — | — | 1 | 8.60 |
| CHEMBL4583164 | — | — | 1 | 8.54 |
| CHEMBL4576689 | — | — | 1 | 8.54 |
| CHEMBL4463844 | — | — | 1 | 8.51 |
| CHEMBL4468834 | — | — | 1 | 8.44 |
| CHEMBL4436290 | — | — | 1 | 8.40 |
| CHEMBL4454599 | — | — | 1 | 8.30 |
| CHEMBL4586089 | — | — | 1 | 8.30 |
| CHEMBL4592616 | — | — | 1 | 8.25 |
| CHEMBL4443095 | — | — | 1 | 8.25 |
| CHEMBL4517317 | — | — | 1 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4513684 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL4451500 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL4446052 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL4437818 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL4475496 | — | Kd | = | 0.83 | nM | 9.08 |
| CHEMBL4442511 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4574321 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4475073 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4588838 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL4584546 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4466140 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4539233 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4450456 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4562296 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4569008 | — | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL4450545 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4593681 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4444201 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL4450306 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL4470832 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL4583164 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL4576689 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL4463844 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4468834 | — | Kd | = | 3.6 | nM | 8.44 |
| CHEMBL4436290 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4454599 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4586089 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4592616 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL4443095 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL4517317 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL4553519 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL4445515 | — | Kd | = | 6.4 | nM | 8.19 |
| CHEMBL4465972 | — | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL4572161 | — | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL4573963 | — | Kd | = | 7.7 | nM | 8.11 |
| CHEMBL4558287 | — | Kd | = | 8.3 | nM | 8.08 |
| CHEMBL4521683 | — | Kd | = | 9.5 | nM | 8.02 |
| CHEMBL4565560 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4565224 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4514121 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4515586 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL4459385 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4579465 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL4582964 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL4468310 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL4456084 | — | Kd | = | 30.0 | nM | 7.52 |
| CHEMBL4551069 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL4469236 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL4566236 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL4168586 | — | Kd | = | 40.0 | nM | 7.40 |