Assay Detail

CHEMBL4316875

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Functional

Antiproliferative activity against human LoVo cells by SRB assay

ChEMBL ↗

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Target

LoVo (CHEMBL614721) ↗

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Primary target LoVo

CHEMBL614721

Anchored from Assay target.

Protein identity LoVo

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LoVo
Confidence	1 — Organism
Curated By	Autocuration

Target

LoVo (CHEMBL614721) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.

Antoszczak M.
Eur J Med Chem (2019) 166 : 48 -64
PubMed 30684870 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.14	6.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1208572	SALINOMYCIN	2.0	1	6.36
CHEMBL4437686	—	—	1	5.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1208572	SALINOMYCIN	IC50	=	440.0	nM	6.36
CHEMBL4437686	—	IC50	=	1200.0	nM	5.92