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Assay Detail

CHEMBL4317022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sodium channel (unknown origin) at tonic phase by patch clamp assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
Wang X, Blackaby W, Allen V, Chan GKY, Chang JH, Chiang PC, Diène C, Drummond J, Do S, Fan E, Harstad EB, Hodges A, Hu H, Jia W, Kofie W, Kolesnikov A, Lyssikatos JP, Ly J, Matteucci M, Moffat JG, Munugalavadla V, Murray J, Nash D, Noland CL, Del Rosario G, Ross L, Rouse C, Sharpe A, Slaga D, Sun M, Tsui V, Wallweber H, Yu SF, Ebens AJ.
J Med Chem (2019) 62 : 2140 -2153
PubMed 30715878 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.94 4.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3648680 1 4.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3648680 IC50 = 11500.0 nM 4.94