Assay Detail
Functional
CHEMBL4320489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.11 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463727 | — | — | 1 | 6.64 |
| CHEMBL4580765 | — | — | 1 | 6.58 |
| CHEMBL4556684 | — | — | 1 | 6.54 |
| CHEMBL4550994 | — | — | 1 | 6.38 |
| CHEMBL4554953 | — | — | 1 | 6.05 |
| CHEMBL4463937 | — | — | 1 | 5.86 |
| CHEMBL4476797 | — | — | 1 | 5.70 |
| CHEMBL4437525 | — | — | 1 | 5.67 |
| CHEMBL4298697 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463727 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4580765 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4556684 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4550994 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4554953 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4463937 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4476797 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4437525 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4298697 | — | IC50 | = | 2680.0 | nM | 5.57 |