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Assay Detail

CHEMBL4321982

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sonic hedgehog signaling in mouse Shh Light2 cells after 30 mins by Bright-Glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sonic hedgehog protein (CHEMBL5387)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.
Galperin I, Dempwolff L, Diederich WE, Lauth M.
J Med Chem (2019) 62 : 8392 -8411
PubMed 30986059 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.40 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL473392 ROBOTNIKININ 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL473392 ROBOTNIKININ IC50 = 4000.0 nM 5.40