Assay Detail
Binding
CHEMBL4322005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL3414411) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na<sub>V</sub>1.7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.74 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3662190 | — | — | 1 | 8.66 |
| CHEMBL4588728 | — | — | 1 | 8.36 |
| CHEMBL3945969 | — | — | 2 | 7.77 |
| CHEMBL4217988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3662190 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4588728 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3945969 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3945969 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4217988 | — | IC50 | < | 0.1 | nM | - |