Assay Detail

CHEMBL4322144

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Binding

Inhibition of Kinesin Eg5 (unknown origin)

ChEMBL ↗

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Target

Kinesin-like protein KIF11 (CHEMBL4581) ↗

Open DB target context

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Kinesin-like protein KIF11 (CHEMBL4581) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Kinesin-like protein KIF11

CHEMBL4581

Anchored from Assay target.

Protein identity Kinesin-like protein KIF11

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Kinesin-like protein KIF11 (CHEMBL4581) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Why Some Targets Benefit from beyond Rule of Five Drugs.

Egbert M, Whitty A, Keserű GM, Vajda S.
J Med Chem (2019) 62 : 10005 -10025
PubMed 31188592 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.64	8.64
IC50	1	5.70	5.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL228814	ISPINESIB	2.0	1	8.64
CHEMBL1213954	(S)-ENASTRON	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL228814	ISPINESIB	Ki	=	2.3	nM	8.64
CHEMBL1213954	(S)-ENASTRON	IC50	=	2000.0	nM	5.70