Assay Detail
Binding
CHEMBL4322147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HMG-CoA Reductase (unknown origin)
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Why Some Targets Benefit from beyond Rule of Five Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.21 | 8.21 |
| IC50 | 1 | 7.64 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 8.21 |
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1487 | ATORVASTATIN | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL54440 | MEVASTATIN | IC50 | = | 23.0 | nM | 7.64 |