Assay Detail
Binding
CHEMBL4322151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat TASK3 expressed in (FRT) epithelial cells by chamber based electrophysiology assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 9 (CHEMBL4295) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
TASK Channels Pharmacology: New Challenges in Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.75 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324344 | — | — | 1 | 8.00 |
| CHEMBL148342 | — | — | 1 | 7.44 |
| CHEMBL1754 | DOXAPRAM | 4.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324344 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL148342 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1754 | DOXAPRAM | IC50 | = | 16000.0 | nM | 4.80 |