Assay Detail
Functional
CHEMBL4322185
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Antifibrotic activity against mouse Mlg2908 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554638 | — | — | 1 | 8.70 |
| CHEMBL4538966 | — | — | 1 | 8.52 |
| CHEMBL4527563 | — | — | 1 | 8.52 |
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 8.40 |
| CHEMBL4528382 | — | — | 1 | 8.40 |
| CHEMBL4450219 | — | — | 1 | 8.30 |
| CHEMBL4574739 | — | — | 1 | 8.10 |
| CHEMBL4531499 | — | — | 1 | 8.00 |
| CHEMBL4440542 | — | — | 1 | 7.89 |
| CHEMBL4452913 | — | — | 1 | 7.82 |
| CHEMBL4580784 | — | — | 1 | 7.70 |
| CHEMBL4585873 | — | — | 1 | 7.48 |
| CHEMBL4561621 | — | — | 1 | 7.09 |
| CHEMBL4517643 | — | — | 1 | 6.89 |
| CHEMBL4466982 | — | — | 1 | 6.89 |
| CHEMBL4166144 | — | — | 1 | 6.85 |
| CHEMBL4547768 | — | — | 1 | 6.68 |
| CHEMBL4473566 | — | — | 1 | 6.64 |
| CHEMBL4443519 | — | — | 1 | 6.34 |
| CHEMBL3984425 | EGANELISIB | 2.0 | 1 | 6.01 |
| CHEMBL4548696 | — | — | 1 | 5.89 |
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 5.46 |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 5.16 |
| CHEMBL4516782 | — | — | 1 | 4.77 |
| CHEMBL3188551 | GSK-2636771 | 2.0 | 1 | - |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554638 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4538966 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4527563 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4528382 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4450219 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4574739 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4531499 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4440542 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4452913 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4580784 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4585873 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4561621 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4517643 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4466982 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4166144 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4547768 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4473566 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4443519 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3984425 | EGANELISIB | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4548696 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2396661 | ALPELISIB | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3039502 | DUVELISIB | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4516782 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3188551 | GSK-2636771 | IC50 | > | 20000.0 | nM | - |
| CHEMBL2216870 | IDELALISIB | IC50 | > | 20000.0 | nM | - |