Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4322380

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HADC1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.
Brindisi M, Saraswati AP, Brogi S, Gemma S, Butini S, Campiani G.
J Med Chem (2020) 63 : 23 -39
PubMed 31415174 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.60 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL343448 ROMIDEPSIN 4.0 1 8.80
CHEMBL3126832 OBP-801 1.0 1 8.48
CHEMBL99 TRICHOSTATIN 1.0 1 8.22
CHEMBL98 VORINOSTAT 4.0 1 7.48
CHEMBL2364628 RICOLINOSTAT 2.0 1 7.24
CHEMBL3655950 1 7.03
CHEMBL27759 ENTINOSTAT 3.0 1 6.29
CHEMBL96051 SCRIPTAID 1 6.22
CHEMBL356769 TUBACIN 1 5.85
CHEMBL3655978 1 5.67
CHEMBL4080014 1 5.37
CHEMBL2018302 TUBASTATIN A 1 4.79
CHEMBL109 VALPROIC ACID 4.0 1 4.40
CHEMBL483254 PANOBINOSTAT 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL343448 ROMIDEPSIN IC50 = 1.6 nM 8.80
CHEMBL3126832 OBP-801 IC50 = 3.3 nM 8.48
CHEMBL99 TRICHOSTATIN IC50 = 6.0 nM 8.22
CHEMBL98 VORINOSTAT IC50 = 33.0 nM 7.48
CHEMBL2364628 RICOLINOSTAT IC50 = 58.0 nM 7.24
CHEMBL3655950 IC50 = 94.0 nM 7.03
CHEMBL27759 ENTINOSTAT IC50 = 510.0 nM 6.29
CHEMBL96051 SCRIPTAID IC50 = 600.0 nM 6.22
CHEMBL356769 TUBACIN IC50 = 1400.0 nM 5.85
CHEMBL3655978 IC50 = 2123.0 nM 5.67
CHEMBL4080014 IC50 = 4320.0 nM 5.37
CHEMBL2018302 TUBASTATIN A IC50 = 16400.0 nM 4.79
CHEMBL109 VALPROIC ACID IC50 = 40000.0 nM 4.40
CHEMBL483254 PANOBINOSTAT IC50 < 15.0 nM -