Assay Detail
Binding
CHEMBL4322386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 5 group A member 2 (CHEMBL3544) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.03 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440757 | — | — | 1 | 7.82 |
| CHEMBL4447391 | — | — | 1 | 7.40 |
| CHEMBL4565513 | — | — | 1 | 7.00 |
| CHEMBL4541939 | — | — | 1 | 6.30 |
| CHEMBL4558553 | — | — | 1 | 6.10 |
| CHEMBL4455426 | — | — | 1 | 6.10 |
| CHEMBL4461328 | — | — | 1 | 6.05 |
| CHEMBL4452061 | — | — | 1 | 6.05 |
| CHEMBL4460749 | — | — | 1 | 6.00 |
| CHEMBL1765959 | — | — | 1 | 5.82 |
| CHEMBL4471992 | — | — | 1 | 5.70 |
| CHEMBL4562317 | — | — | 1 | 5.52 |
| CHEMBL4574667 | — | — | 1 | 5.40 |
| CHEMBL4527695 | — | — | 1 | 5.30 |
| CHEMBL4514240 | — | — | 1 | 5.05 |
| CHEMBL4559668 | — | — | 1 | 4.89 |
| CHEMBL4458433 | — | — | 1 | - |
| CHEMBL4569459 | — | — | 1 | - |
| CHEMBL4465557 | — | — | 1 | - |
| CHEMBL4587527 | — | — | 1 | - |
| CHEMBL4557693 | — | — | 1 | - |
| CHEMBL4532173 | — | — | 1 | - |
| CHEMBL4452639 | — | — | 1 | - |
| CHEMBL4555039 | — | — | 1 | - |
| CHEMBL4558333 | — | — | 1 | - |
| CHEMBL4552141 | — | — | 1 | - |
| CHEMBL4569856 | — | — | 1 | - |
| CHEMBL4572760 | — | — | 1 | - |
| CHEMBL4435095 | — | — | 1 | - |
| CHEMBL4464683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440757 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4447391 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4565513 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4541939 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4558553 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4455426 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4461328 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4452061 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4460749 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1765959 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4471992 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4562317 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4574667 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4527695 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4514240 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4559668 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4566367 | — | EC50 | - | — | - | |
| CHEMBL4464206 | — | EC50 | - | — | - | |
| CHEMBL4464683 | — | EC50 | - | — | - | |
| CHEMBL4435095 | — | EC50 | - | — | - | |
| CHEMBL4572760 | — | EC50 | - | — | - | |
| CHEMBL4569856 | — | EC50 | - | — | - | |
| CHEMBL4552141 | — | EC50 | - | — | - | |
| CHEMBL4558333 | — | EC50 | - | — | - | |
| CHEMBL4555039 | — | EC50 | - | — | - | |
| CHEMBL4452639 | — | EC50 | - | — | - | |
| CHEMBL4532173 | — | EC50 | - | — | - | |
| CHEMBL4557693 | — | EC50 | - | — | - | |
| CHEMBL4587527 | — | EC50 | - | — | - | |
| CHEMBL4465557 | — | EC50 | - | — | - | |
| CHEMBL4569459 | — | EC50 | - | — | - | |
| CHEMBL4458433 | — | EC50 | - | — | - |