Assay Detail
Binding
CHEMBL4322445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pseudomonas aeruginosa class D serine beta-lactamase OXA-10 expressed in Escherichia coli BL21(DE3) cells assessed as reduction in breakdown of cephalosporin FC-5 in presence of aqueous sodium bicarbonate after 10 to 300 mins by fluorescence method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.29 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4533632 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4533632 | — | IC50 | = | 5100.0 | nM | 5.29 |