Assay Detail
Binding
CHEMBL4322449
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Inhibition of bacterial class B1 metallo beta-lactamase VIM-1 assessed as reduction in breakdown of cephalosporin FC-5 after 10 mins by fluorescence method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.59 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463697 | — | — | 1 | 8.10 |
| CHEMBL4533632 | — | — | 1 | 7.07 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463697 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4533632 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3317857 | VABORBACTAM | IC50 | = | 398000.0 | nM | - |