Assay Detail
Binding
CHEMBL4322503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.36 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4286698 | — | — | 1 | 9.57 |
| CHEMBL4574759 | — | — | 1 | 8.46 |
| CHEMBL4551080 | — | — | 1 | 8.46 |
| CHEMBL4436124 | — | — | 1 | 7.85 |
| CHEMBL4594206 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4286698 | — | Kd | = | 0.27 | nM | 9.57 |
| CHEMBL4574759 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL4551080 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL4436124 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL4594206 | — | Kd | = | 34.0 | nM | 7.47 |