Assay Detail
Binding
CHEMBL4323765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at alphaVbeta3 integrin receptor in human SK-MEL-24 cells assessed as reduction in fibronectin-induced cell adhesion pre-incubated for 30 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-24 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.92 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4461771 | — | — | 1 | 7.39 |
| CHEMBL4461668 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4461771 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL4461668 | — | IC50 | = | 352.0 | nM | 6.45 |