Assay Detail
Binding
CHEMBL4323767
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Antagonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as reduction in fibronectin-induced cell adhesion pre-incubated for 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4575577 | — | — | 1 | 7.38 |
| CHEMBL4593469 | — | — | 1 | 7.01 |
| CHEMBL4461668 | — | — | 1 | 6.80 |
| CHEMBL4534088 | — | — | 1 | 6.38 |
| CHEMBL4585226 | — | — | 1 | 5.96 |
| CHEMBL4454796 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4575577 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL4593469 | — | IC50 | = | 96.9 | nM | 7.01 |
| CHEMBL4461668 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4534088 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL4585226 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4454796 | — | IC50 | = | 3512.0 | nM | 5.45 |