Assay Detail
Binding
CHEMBL4323768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4586928 | — | — | 1 | 8.00 |
| CHEMBL4442651 | — | — | 1 | 6.85 |
| CHEMBL3289606 | — | — | 1 | 6.44 |
| CHEMBL4461771 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4586928 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4442651 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3289606 | — | EC50 | = | 365.0 | nM | 6.44 |
| CHEMBL4461771 | — | EC50 | = | 1031.0 | nM | 5.99 |