Assay Detail
Binding
CHEMBL4323769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha4beta1 integrin receptor in human Jurkat E6.1 cells assessed as increase in VCAM1-induced cell adhesion pre-incubated for 30 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.12 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442651 | — | — | 1 | 8.00 |
| CHEMBL4589062 | — | — | 1 | 7.89 |
| CHEMBL4446073 | — | — | 1 | 6.59 |
| CHEMBL4447762 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442651 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4589062 | — | EC50 | = | 12.9 | nM | 7.89 |
| CHEMBL4446073 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL4447762 | — | EC50 | = | 976.0 | nM | 6.01 |