Assay Detail
Binding
CHEMBL4324124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.08 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.09 |
| CHEMBL4537790 | — | — | 1 | 6.72 |
| CHEMBL4566193 | — | — | 1 | 6.57 |
| CHEMBL4532034 | — | — | 1 | 6.16 |
| CHEMBL4562138 | — | — | 1 | 5.96 |
| CHEMBL4519157 | — | — | 1 | 5.89 |
| CHEMBL4550104 | — | — | 1 | 5.64 |
| CHEMBL4449589 | — | — | 1 | 5.44 |
| CHEMBL4525935 | — | — | 1 | 5.29 |
| CHEMBL4434788 | — | — | 1 | - |
| CHEMBL4591327 | — | — | 1 | - |
| CHEMBL4444231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4537790 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4566193 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4532034 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4562138 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4519157 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4550104 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4449589 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4525935 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4434788 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4591327 | — | IC50 | - | — | - | |
| CHEMBL4444231 | — | IC50 | - | — | - |