Assay Detail

CHEMBL4324281

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Binding

Inhibition of NS5A in HCV genotype 2a JFH-1 by cell based luciferase reporter gene assay

ChEMBL ↗

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Target

Nonstructural protein 5A (CHEMBL3307224) ↗

Open DB target context

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Nonstructural protein 5A (CHEMBL3307224) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Nonstructural protein 5A

CHEMBL3307224

Anchored from Assay target.

Protein identity Nonstructural protein 5A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 2a
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Nonstructural protein 5A (CHEMBL3307224) ↗

Type	SINGLE PROTEIN
Organism	Hepatitis C virus

Publication

Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate.

Ramdas V, Talwar R, Banerjee M, Joshi AA, Das AK, Walke DS, Borhade P, Dhayagude U, Loriya R, Gote G, Bommakanti A, Sivaram A, Agarwal G, Goswami A, Nigade P, Mehta M, Patil V, Modi D, Kumar H, Mallurwar S, Dash A, Modi F, Kuldharan S, Srivastava P, Singh M, Narasimham L, Gundu J, Sharma S, Kamboj RK, Palle VP.
J Med Chem (2019) 62 : 10563 -10582
PubMed 31710479 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.68	7.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2374220	LEDIPASVIR	4.0	1	7.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2374220	LEDIPASVIR	IC50	=	21.0	nM	7.68