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Assay Detail

CHEMBL4325428

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Functional
Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Yang Y, Zhang R, Li Z, Mei L, Wan S, Ding H, Chen Z, Xing J, Feng H, Han J, Jiang H, Zheng M, Luo C, Zhou B.
J Med Chem (2020) 63 : 1337 -1360
PubMed 31910017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.64 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4457144 1 8.54
CHEMBL4567310 1 8.46
CHEMBL4474109 1 8.43
CHEMBL4475351 1 8.40
CHEMBL4587968 1 8.38
CHEMBL4449940 1 8.32
CHEMBL4449592 1 8.09
CHEMBL4552724 1 8.06
CHEMBL4593536 1 7.97
CHEMBL4474031 1 7.92
CHEMBL4450724 1 7.87
CHEMBL4439084 1 7.80
CHEMBL4452911 1 7.69
CHEMBL4464962 1 7.60
CHEMBL4524352 1 7.19
CHEMBL4584269 1 7.14
CHEMBL4513653 1 7.11
CHEMBL4456527 1 6.93
CHEMBL4472048 1 6.81
CHEMBL4441280 1 6.69
CHEMBL4282264 A-485 1 6.59
CHEMBL4519167 1 6.08
CHEMBL4582713 1 -
CHEMBL4566439 1 -
CHEMBL4436959 1 -
CHEMBL4446240 1 -
CHEMBL4464151 1 -
CHEMBL4525368 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4457144 IC50 = 2.9 nM 8.54
CHEMBL4567310 IC50 = 3.5 nM 8.46
CHEMBL4474109 IC50 = 3.7 nM 8.43
CHEMBL4475351 IC50 = 4.0 nM 8.40
CHEMBL4587968 IC50 = 4.2 nM 8.38
CHEMBL4449940 IC50 = 4.8 nM 8.32
CHEMBL4449592 IC50 = 8.2 nM 8.09
CHEMBL4552724 IC50 = 8.8 nM 8.06
CHEMBL4593536 IC50 = 10.7 nM 7.97
CHEMBL4474031 IC50 = 12.0 nM 7.92
CHEMBL4450724 IC50 = 13.5 nM 7.87
CHEMBL4439084 IC50 = 15.8 nM 7.80
CHEMBL4452911 IC50 = 20.4 nM 7.69
CHEMBL4464962 IC50 = 24.9 nM 7.60
CHEMBL4524352 IC50 = 64.3 nM 7.19
CHEMBL4584269 IC50 = 72.8 nM 7.14
CHEMBL4513653 IC50 = 77.0 nM 7.11
CHEMBL4456527 IC50 = 118.0 nM 6.93
CHEMBL4472048 IC50 = 156.3 nM 6.81
CHEMBL4441280 IC50 = 206.0 nM 6.69
CHEMBL4282264 A-485 IC50 = 255.2 nM 6.59
CHEMBL4519167 IC50 = 825.0 nM 6.08
CHEMBL4582713 IC50 > 500.0 nM -
CHEMBL4566439 IC50 > 1000.0 nM -
CHEMBL4436959 IC50 - -
CHEMBL4446240 IC50 > 1000.0 nM -
CHEMBL4464151 IC50 > 5000.0 nM -
CHEMBL4525368 IC50 > 5000.0 nM -