Assay Detail
Functional
CHEMBL4326151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL1881) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 7.67 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3707245 | OMIDENEPAG | 2.0 | 1 | 8.96 |
| CHEMBL4467099 | — | — | 1 | 8.80 |
| CHEMBL4471378 | — | — | 1 | 8.70 |
| CHEMBL4515583 | — | — | 1 | 8.59 |
| CHEMBL4466224 | — | — | 1 | 8.57 |
| CHEMBL4442505 | — | — | 1 | 8.57 |
| CHEMBL4591201 | — | — | 1 | 8.55 |
| CHEMBL4476670 | — | — | 1 | 8.47 |
| CHEMBL4456588 | — | — | 1 | 8.37 |
| CHEMBL4447271 | — | — | 1 | 8.36 |
| CHEMBL4458330 | — | — | 1 | 8.35 |
| CHEMBL4470479 | — | — | 1 | 8.25 |
| CHEMBL4587628 | — | — | 1 | 8.21 |
| CHEMBL4594090 | — | — | 1 | 7.89 |
| CHEMBL2105672 | EVATANEPAG SODIUM | -1.0 | 1 | 7.77 |
| CHEMBL4462507 | — | — | 1 | 7.75 |
| CHEMBL4548451 | — | — | 1 | 7.72 |
| CHEMBL4466523 | — | — | 1 | 7.54 |
| CHEMBL4449902 | — | — | 1 | 7.46 |
| CHEMBL4449855 | — | — | 1 | 7.37 |
| CHEMBL4561017 | — | — | 1 | 7.35 |
| CHEMBL4531171 | — | — | 1 | 7.12 |
| CHEMBL4451941 | — | — | 1 | 7.08 |
| CHEMBL4554216 | — | — | 1 | 7.04 |
| CHEMBL4566584 | — | — | 1 | 6.96 |
| CHEMBL4539881 | — | — | 1 | 6.93 |
| CHEMBL4451786 | — | — | 1 | 6.92 |
| CHEMBL4519118 | — | — | 1 | 6.55 |
| CHEMBL4473407 | — | — | 1 | 6.51 |
| CHEMBL4521659 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3707245 | OMIDENEPAG | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4467099 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4471378 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4515583 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4466224 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4442505 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4591201 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4476670 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4456588 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4447271 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4458330 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4470479 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4587628 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4594090 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2105672 | EVATANEPAG SODIUM | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4462507 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4548451 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4466523 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4449902 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4449855 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4561017 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4531171 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4451941 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4554216 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4566584 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4539881 | — | EC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4451786 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4519118 | — | EC50 | = | 283.0 | nM | 6.55 |
| CHEMBL4473407 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4521659 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4460294 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4514124 | — | EC50 | = | 649.0 | nM | 6.19 |
| CHEMBL4527224 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4593898 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4586861 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4467297 | — | EC50 | > | 1000.0 | nM | - |