Assay Detail
Binding
CHEMBL4326249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 after 30 mins using fluorogenic substrate by fluorimetric assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.82 |
| CHEMBL2170177 | — | — | 1 | 5.51 |
| CHEMBL4460757 | — | — | 1 | 5.42 |
| CHEMBL4517272 | — | — | 1 | 5.30 |
| CHEMBL4448903 | — | — | 1 | 5.16 |
| CHEMBL4542119 | — | — | 1 | 4.82 |
| CHEMBL4452476 | — | — | 1 | - |
| CHEMBL498271 | — | — | 1 | - |
| CHEMBL96051 | SCRIPTAID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2170177 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4460757 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4517272 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4448903 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4542119 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4452476 | — | IC50 | - | — | - | |
| CHEMBL498271 | — | IC50 | - | — | - | |
| CHEMBL96051 | SCRIPTAID | IC50 | - | — | - |