Assay Detail
Binding
CHEMBL4326431
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Inhibition of full length human p110alpha/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assay
4
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.65 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470860 | — | — | 3 | 6.73 |
| CHEMBL4460625 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470860 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4460625 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4470860 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4470860 | — | IC50 | > | 10000.0 | nM | - |