Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4326559

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB cells after 3 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents.
Le-Nhat-Thuy G, Dinh TV, Pham-The H, Nguyen Quang H, Nguyen Thi N, Dang Thi TA, Hoang Thi P, Le Thi TA, Nguyen HT, Nguyen Thanh P, Le Duc T, Nguyen TV.
Bioorg Med Chem Lett (2018) 28 : 3741 -3747
PubMed 30337229 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.19 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4583159 1 7.40
CHEMBL4587309 1 6.57
CHEMBL4466177 1 5.84
CHEMBL4531662 1 5.83
CHEMBL123 ELLIPTECINE 1 5.71
CHEMBL4453068 1 5.58
CHEMBL4573630 1 5.46
CHEMBL4467337 1 5.34
CHEMBL4571565 1 5.26
CHEMBL4451297 1 5.26
CHEMBL4543981 1 5.26
CHEMBL4588686 1 5.20
CHEMBL553 ERLOTINIB 4.0 1 4.89
CHEMBL4438076 1 4.69
CHEMBL4558451 1 4.52
CHEMBL1079742 ERLOTINIB HYDROCHLORIDE 4.0 1 4.30
CHEMBL4443344 1 4.27
CHEMBL4461312 1 4.26
CHEMBL4475630 1 4.12
CHEMBL4562863 1 4.10
CHEMBL4447755 1 -
CHEMBL4467781 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4583159 IC50 = 40.0 nM 7.40
CHEMBL4587309 IC50 = 270.0 nM 6.57
CHEMBL4466177 IC50 = 1460.0 nM 5.84
CHEMBL4531662 IC50 = 1490.0 nM 5.83
CHEMBL123 ELLIPTECINE IC50 = 1950.0 nM 5.71
CHEMBL4453068 IC50 = 2600.0 nM 5.58
CHEMBL4573630 IC50 = 3510.0 nM 5.46
CHEMBL4467337 IC50 = 4590.0 nM 5.34
CHEMBL4571565 IC50 = 5460.0 nM 5.26
CHEMBL4451297 IC50 = 5500.0 nM 5.26
CHEMBL4543981 IC50 = 5470.0 nM 5.26
CHEMBL4588686 IC50 = 6350.0 nM 5.20
CHEMBL553 ERLOTINIB IC50 = 13010.0 nM 4.89
CHEMBL4438076 IC50 = 20440.0 nM 4.69
CHEMBL4558451 IC50 = 30100.0 nM 4.52
CHEMBL1079742 ERLOTINIB HYDROCHLORIDE IC50 = 49620.0 nM 4.30
CHEMBL4443344 IC50 = 53170.0 nM 4.27
CHEMBL4461312 IC50 = 54830.0 nM 4.26
CHEMBL4475630 IC50 = 75600.0 nM 4.12
CHEMBL4562863 IC50 = 79090.0 nM 4.10
CHEMBL4447755 IC50 = 193330.0 nM -
CHEMBL4467781 IC50 = 104200.0 nM -