Assay Detail
Functional
CHEMBL4326560
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Cytotoxicity against human HepG2 cells after 3 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.19 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583159 | — | — | 1 | 6.85 |
| CHEMBL4573630 | — | — | 1 | 6.06 |
| CHEMBL4531662 | — | — | 1 | 5.79 |
| CHEMBL4466177 | — | — | 1 | 5.73 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.57 |
| CHEMBL4453068 | — | — | 1 | 5.55 |
| CHEMBL4571565 | — | — | 1 | 5.38 |
| CHEMBL4451297 | — | — | 1 | 5.33 |
| CHEMBL4467337 | — | — | 1 | 5.21 |
| CHEMBL4587309 | — | — | 1 | 5.21 |
| CHEMBL4588686 | — | — | 1 | 5.16 |
| CHEMBL4543981 | — | — | 1 | 5.09 |
| CHEMBL4558451 | — | — | 1 | 4.95 |
| CHEMBL1079742 | ERLOTINIB HYDROCHLORIDE | 4.0 | 1 | 4.85 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.60 |
| CHEMBL4475630 | — | — | 1 | 4.58 |
| CHEMBL4438076 | — | — | 1 | 4.36 |
| CHEMBL4461312 | — | — | 1 | 4.16 |
| CHEMBL4443344 | — | — | 1 | 4.12 |
| CHEMBL4562863 | — | — | 1 | - |
| CHEMBL4467781 | — | — | 1 | - |
| CHEMBL4447755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583159 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4573630 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4531662 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4466177 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4453068 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4571565 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4451297 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL4467337 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4587309 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4588686 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4543981 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL4558451 | — | IC50 | = | 11290.0 | nM | 4.95 |
| CHEMBL1079742 | ERLOTINIB HYDROCHLORIDE | IC50 | = | 14170.0 | nM | 4.85 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 25010.0 | nM | 4.60 |
| CHEMBL4475630 | — | IC50 | = | 26170.0 | nM | 4.58 |
| CHEMBL4438076 | — | IC50 | = | 43350.0 | nM | 4.36 |
| CHEMBL4461312 | — | IC50 | = | 69890.0 | nM | 4.16 |
| CHEMBL4443344 | — | IC50 | = | 76810.0 | nM | 4.12 |
| CHEMBL4562863 | — | IC50 | = | 230020.0 | nM | - |
| CHEMBL4467781 | — | IC50 | = | 286750.0 | nM | - |
| CHEMBL4447755 | — | IC50 | = | 207010.0 | nM | - |