Assay Detail
Binding
CHEMBL4327282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC6 using RHK-K(Ac) as substrate by homogeneous fluorescence release assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.70 |
| CHEMBL4593437 | — | — | 1 | 8.05 |
| CHEMBL4476057 | — | — | 1 | 7.92 |
| CHEMBL4550522 | — | — | 1 | 7.82 |
| CHEMBL4469596 | — | — | 1 | 7.77 |
| CHEMBL4521590 | — | — | 1 | 7.58 |
| CHEMBL4435005 | — | — | 1 | 7.43 |
| CHEMBL3110004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4593437 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4476057 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4550522 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4469596 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4521590 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4435005 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3110004 | — | IC50 | - | — | - |