Assay Detail
Functional
CHEMBL4327289
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Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation measured after 48 hrs by microbeta liquid scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.81 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426803 | — | — | 1 | 8.40 |
| CHEMBL4461581 | — | — | 1 | 8.21 |
| CHEMBL569864 | — | — | 1 | 8.01 |
| CHEMBL4550522 | — | — | 1 | 7.87 |
| CHEMBL1231795 | — | — | 1 | 7.78 |
| CHEMBL4558658 | — | — | 1 | 7.73 |
| CHEMBL4537137 | — | — | 1 | 7.37 |
| CHEMBL4527662 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426803 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4461581 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL569864 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4550522 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL1231795 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL4558658 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL4537137 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL4527662 | — | IC50 | = | 81.3 | nM | 7.09 |