Assay Detail
Binding
CHEMBL4327326
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Inhibition of recombinant human MAO-A expressed in baculovirus infected insect cell microsomes using kynuramine as substrate measured after 30 mins by fluorescence based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.00 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.42 |
| CHEMBL4459482 | — | — | 1 | 6.64 |
| CHEMBL4470448 | — | — | 1 | 6.26 |
| CHEMBL4450310 | — | — | 1 | 5.96 |
| CHEMBL4578377 | — | — | 1 | 5.92 |
| CHEMBL4580662 | — | — | 1 | 5.85 |
| CHEMBL4550762 | — | — | 1 | 5.77 |
| CHEMBL4450045 | — | — | 1 | 5.72 |
| CHEMBL4551962 | — | — | 1 | 5.66 |
| CHEMBL4468552 | — | — | 1 | 5.46 |
| CHEMBL4529750 | — | — | 1 | 5.41 |
| CHEMBL4466686 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4459482 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4470448 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4450310 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4578377 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4580662 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4550762 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4450045 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4551962 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4468552 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4529750 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4466686 | — | IC50 | = | 11000.0 | nM | 4.96 |