Assay Detail
Binding
CHEMBL4328668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKA (unknown origin)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.97 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434688 | — | — | 1 | 8.10 |
| CHEMBL4472858 | — | — | 1 | 7.24 |
| CHEMBL4459077 | — | — | 1 | 7.19 |
| CHEMBL4583341 | — | — | 1 | 7.02 |
| CHEMBL4536833 | — | — | 1 | 6.96 |
| CHEMBL4448806 | — | — | 1 | 6.62 |
| CHEMBL4521871 | — | — | 1 | 6.48 |
| CHEMBL4474946 | — | — | 1 | 6.47 |
| CHEMBL4469316 | — | — | 1 | 6.44 |
| CHEMBL2006299 | — | — | 1 | 6.07 |
| CHEMBL4553926 | — | — | 1 | 6.06 |
| CHEMBL4557041 | — | — | 1 | 6.06 |
| CHEMBL4522042 | — | — | 1 | 6.04 |
| CHEMBL1977135 | — | — | 1 | 6.03 |
| CHEMBL4436197 | — | — | 1 | 6.00 |
| CHEMBL4572198 | — | — | 1 | 6.00 |
| CHEMBL4459800 | — | — | 1 | 5.92 |
| CHEMBL4460511 | — | — | 1 | 5.70 |
| CHEMBL4436040 | — | — | 1 | 5.64 |
| CHEMBL4555093 | — | — | 1 | 5.64 |
| CHEMBL4465725 | — | — | 1 | 5.48 |
| CHEMBL4463301 | — | — | 1 | 5.34 |
| CHEMBL4438453 | — | — | 1 | 5.24 |
| CHEMBL4475535 | — | — | 1 | 5.15 |
| CHEMBL4454552 | — | — | 1 | 5.13 |
| CHEMBL4451899 | — | — | 1 | 5.11 |
| CHEMBL4556370 | — | — | 1 | 5.10 |
| CHEMBL4476761 | — | — | 1 | 5.00 |
| CHEMBL4447521 | — | — | 1 | 5.00 |
| CHEMBL4570150 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434688 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4472858 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4459077 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4583341 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4536833 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4448806 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4521871 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4474946 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4469316 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2006299 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4553926 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4557041 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4522042 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1977135 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4572198 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4436197 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4459800 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4460511 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4436040 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4555093 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4465725 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4463301 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4438453 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4475535 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4454552 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4451899 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4556370 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4476761 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4447521 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4570150 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4568447 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446212 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4588929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4445356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4540054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4471862 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4575880 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4590232 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4469434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4550282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547725 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4577208 | — | IC50 | > | 10000.0 | nM | - |