Assay Detail

CHEMBL4328710

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Binding

Inhibition of ROCK2 (unknown origin) incubated for 2 hrs by AbbVie kinase panel assay

ChEMBL ↗

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Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Open DB target context

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Rho-associated protein kinase 2 (CHEMBL2973) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rho-associated protein kinase 2

CHEMBL2973

Anchored from Assay target.

Protein identity Rho-associated protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.

Hobson AD, Judge RA, Aguirre AL, Brown BS, Cui Y, Ding P, Dominguez E, DiGiammarino E, Egan DA, Freiberg GM, Gopalakrishnan SM, Harris CM, Honore MP, Kage KL, Kapecki NJ, Ling C, Ma J, Mack H, Mamo M, Maurus S, McRae B, Moore NS, Mueller BK, Mueller R, Namovic MT, Patel K, Pratt SD, Putman CB, Queeney KL, Sarris KK, Schaffter LM, Stoll V, Vasudevan A, Wang L, Wang L, Wirthl W, Yach K.
J Med Chem (2018) 61 : 11074 -11100
PubMed 30384606 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.00	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4448806	—	—	1	9.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4448806	—	IC50	=	1.0	nM	9.00